FTIR Imaging of biological samples

Working Group
Department of Life and Environmental Sciences and Department of Biomedical Sciences and Public Health (UNIVPM); ELETTRA-Sincrotrone Trieste.
  • Spectroscopic characterization of biological samples, such as tissue sections from surgical resection or biopsy of various districts, to obtain important information about the composition and distribution of the main biomolecules (proteins, nucleic acids, lipids and carbohydrates).
  • Identification of specific spectral markers to distinguish the different degrees of malignancy in tumor pathologies, to confirm and support the results obtained from the common molecular diagnostic tests;
  • In vitro IR analysis of primary tumor cell lines, study of their biochemical composition and cell metabolism. Evaluation of the effects deriving from stress situations (chemotherapeutic, thermal and oxidative shock) on tumor cell cultures: analysis of changes in the lipid, protein and carbohydrate components.