Medical imaging is indicated for human pathological (anatomical and physiological) investigations and its effectiveness is attributed to the differences in tissue of radiation attenuation and to the capability of the detective system to transform radiation to visible signals, to create an image and finally to proceed to a specific diagnostic task. Every single system involved in the aforementioned procedure affects the signal transferred out of the detector and plays a critical role in the quality of the image and thus in diagnosis validity. Imaging science and technology are able to show and combine morphological, functional, and metabolic information. During the staging of cancer (i.e., from screening and biopsy guidance for detection up to therapy response and palliation), multiple biomedical imaging techniques are used. A large portion of methods and systems for medical imaging were developed on the basis of accurate detection of ionizing radiation transmitted through or emitted by the human body (e.g., X-ray projection Imaging, Mammography, Computed Tomography (CT) etc.).